副主任医师
邮箱：shan.li@cqu.edu.cn
学习经历
2015/01–2020/08 荷兰鹿特丹伊拉斯姆斯大学，胃肠肝病学，博士（导师：Prof. dr. Maikel Peppelenbosch; Dr. Ron Smits）获国家留学基金委“国家建设高水平大学公派研究生项目”全额资助
2013/09–2014/10 英国谢菲尔德大学，分子医学（肿瘤），硕士（导师：Dr. François Guesdon）
2001/09–2006/06 中国人民解放军第三军医大学（现陆军军医大学），临床医学，学士
工作经历
2023/04–至今 kaiyun开云官方网站附属肿瘤公司肝胆胰肿瘤中心，副主任医师
2022/03–2023/04 陆军军医大学陆军特色医学中心（大坪公司）肝胆外科，副主任医师、副研究员
2020/10–2022/03 陆军军医大学陆军特色医学中心（大坪公司）肝胆外科，主治医师、副研究员
2006/09–2013/07 第三军医大学（现陆军军医大学）附属大坪公司肝胆外科，医师
学术兼职
重庆市抗癌协会胆道肿瘤专委会委员
重市中西医结合学会肝胆外科专委会青年委员
Military Medical Research (SCI期刊) 中青年编委
iMeta (SCI期刊) 青年编委
应邀担任Canadian Journal of Gastroenterology and Hepatology、Scientific Reports、Annals of Translational Medicine、Military Medical Research、Medical Science Monitor等多个SCI期刊评审专家。
研究方向
消化系统肿瘤的分子医学及微生物组学研究；蛋白互作研究
成果
代表性论文
1. Li, S., Fuhler, G. M., Bn, N., Jose, T., Bruno, M. J., Peppelenbosch, M. P., & Konstantinov, S. R. (2017). Pancreatic cyst fluid harbors a unique microbiome. Microbiome, 5(1), 1-13.
2. Li, S., Konstantinov, S. R., Smits, R., & Peppelenbosch, M. P. (2017). Bacterial biofilms in colorectal cancer initiation and progression. Trends in molecular medicine, 23(1), 18-30.
3. Li, S., Peppelenbosch, M. P., & Smits, R. (2019). Bacterial biofilms as a potential contributor to mucinous colorectal cancer formation. Biochimica Et Biophysica Acta (BBA)-Reviews on Cancer, 1872(1), 74-79.
4. Li, S., Lavrijsen, M., Bakker, A., Magierowski, M., Magierowska, K., Liu, P., ... & Smits, R. (2020). Commonly observed RNF43 mutations retain functionality in attenuating Wnt/β-catenin signaling and unlikely confer Wnt-dependency onto colorectal cancers. Oncogene, 39(17), 3458-3472.
5. Peng, Z., Li, S.*, & Pi, R.* (2023). A Giant Cystic Liver Mass in an Elderly Man. Gastroenterology, 165(2), e5-e7.
6. Wei, W., Tang, Y., Peng, Z., Xie, J., Deng, Z., Yuan, T., ... Li, S.*, & Liu, H.* (2023). Minimal-access video-assisted retroperitoneal and/or transperitoneal debridement (VARTD) in the management of infected walled-off pancreatic necrosis with deep extension: initial experience from a prospective single-arm study. European Journal of Medical Research, 28(1), 72.
7. Wang, W., Li, S., Liu, P., Sideras, K., van de Werken, H. J., van der Heide, M., ... & Smits, R. (2019). Oncogenic STRAP supports hepatocellular carcinoma growth by enhancing Wnt/β-catenin signaling. Molecular Cancer Research, 17(2), 521-531.
8. Peng, Z., Li, S., Tang, Y., Wei, W., Pi, R., Liang, X., ... & Liu, H. (2021). Efficacy and safety of EUS-guided choledochoduodenostomy using electrocautery-enhanced lumen-apposing metal stents (ECE-LAMS) in the treatment of biliary obstruction: A systematic review and meta-analysis. Canadian Journal of Gastroenterology and Hepatology, 2021, 1-8.
9. Miao, Z., Zhang, S., Ou, X., Li, S., Ma, Z., Wang, W., ... & Pan, Q. (2020). Estimating the global prevalence, disease progression, and clinical outcome of hepatitis delta virus infection. The Journal of infectious diseases, 221(10), 1677-1687.
10. Wang, W., Liu, P., Lavrijsen, M., Li, S., Zhang, R., Li, S., ... & Smits, R. (2021). Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines. Scientific Reports, 11(1), 7470.
11. Liu, P., Liang, B., Liu, M., Lebbink, J. H., Li, S., Qian, M., ... & Smits, R. (2020). Oncogenic mutations in armadillo repeats 5 and 6 of β-catenin reduce binding to APC, increasing signaling and transcription of target genes. Gastroenterology, 158(4), 1029-1043.
12. Xie, B., Xing, R., Chen, P., Gou, Y., Li, S., Xiao, J., & Dong, J. (2010). Down-regulation of c-Met expression inhibits human HCC cells growth and invasion by RNA interference. Journal of Surgical Research, 162(2), 231-238.
13. Liu, J., Wang, Y., Mu, C., Li, M., Li, K., Li, S., ... & Liu, Y. (2022). Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement. Nature Communications, 13(1), 4308.
14. Cao, W., Li, M., Liu, J., Zhang, S., Noordam, L., Verstegen, M. M., Wang, L., Ma, B., Li, S., ... & Pan, Q. (2020). LGR5 marks targetable tumor-initiating cells in mouse liver cancer. Nature communications, 11(1), 1961.
主持课题
国家自然科学基金面上项目1项：ATOH1单泛素化修饰增强其蛋白稳定性促进结直肠癌粘液分化的作用及机制研究，经费55万元，排名第一（批准号：82172857）
