职位：副教授 E-mail: shangze.li@cqu.edu.cn
学习经历：
2011/09-2014/06 武汉大学 博士
2009/09-2011/06 武汉大学 硕士
2004/09-2008/06 成都理工大学/电子科技大学 学士
工作经历：
2021/01-至今， kaiyun开云官方网站，副教授
2017/05-2020/11，武汉大学中南公司/生命科学学院，助理研究员/教授助理
2014/11-2017/03，美国西北大学Feinberg开云全站中国有限公司，博士后研究员
研究方向
本实验室主要从事抗病毒天然免疫信号转导、炎症反应与肿瘤发病机理研究。主要以基因敲除及敲入技术，构建基因突变细胞及小鼠，并通过构建动物疾病模型探索基因在调节免疫稳态及肿瘤发生发展中的功能及机制。
代表性论文（*，第一；#，通讯）
1. Huangheng Tao, Youji Yan, Yixiang Liao, Jiajie Zhou, Jianping Peng, Shangze Li#, Tao Liu# (2021) BRCC3 Promotes Tumourigenesis of Bladder Cancer by Activating the NF‐κB Signal Pathway through Targeting TRAF2, Frontiers in Cell and Developmental Biology (Accepted)
2. Li, C.*, Li, S. Z.*, Huang, X. C., Chen, J., Liu, W., Zhang, X. D., Song, X. M. & Du, R. L. (2021) PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis, Genes Dis. 8, 838-848.
3. Zhang, M. H., Zhang, H. H., Du, X. H., Gao, J., Li, C., Shi, H. R. & Li, S. Z. (2020) UCHL3 promotes ovarian cancer progression by stabilizing TRAF2 to activate the NF-kappaB pathway, Oncogene. 39, 322-333.
4. Li, S. Z.*, #, Shu, Q. P.*, Song, Y., Zhang, H. H., Liu, Y., Jin, B. X., Liuyu, T. Z., Li, C., Huang, X. C., Du, R. L., Song, W., Zhong, B. & Zhang, X. D.# (2019) Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response, Nat Commun. 10, 3233.
5. Li, S.*, Fong, K. W.*, Gritsina, G., Zhang, A., Zhao, J. C., Kim, J., Sharp, A., Yuan, W., Aversa, C., Yang, X. J., Nelson, P. S., Feng, F. Y., Chinnaiyan, A. M., de Bono, J. S., Morrissey, C., Rettig, M. B. & Yu, J. (2019) Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer, Cancer Res. 79, 2580-2592. (Cover letter)
6. Zhao, H., Pan, W. M., Zhang, H. H., Song, Y., Chen, J., Xiang, Y., Gu, B., Li, S. Z.#, Du, R. L. & Zhang, X. D.# (2019) Cancer testis antigen 55 deficiency attenuates colitis-associated colorectal cancer by inhibiting NF-kappaB signaling, Cell Death Dis. 10, 304.
7. Li, S.*, #, Hu, L.*, Li, J., Zhu, J., Zeng, F., Huang, Q., Qiu, L., Du, R. & Cao, R. (2019) Design, synthesis, structure-activity relationships and mechanism of action of new quinoline derivatives as potential antitumor agents, Eur J Med Chem. 162, 666-678.
8. Li, S. Z.*, #, Ren, J. W.*, Fei, J., Zhang, X. D. & Du, R. L. (2019) Cordycepin induces Baxdependent apoptosis in colorectal cancer cells, Mol Med Rep. 19, 901-908.
9. Li, S. Z.*, Zeng, F.*, Li, J., Shu, Q. P., Zhang, H. H., Xu, J., Ren, J. W., Zhang, X. D., Song, X. M. & Du, R. L. (2018) Nemo-like kinase (NLK) primes colorectal cancer progression by releasing the E2F1 complex from HDAC1, Cancer Lett. 431, 43-53.
10. Zhang, H. H.*, Li, S. Z.*, Zhang, Z. Y., Hu, X. M., Hou, P. N., Gao, L., Du, R. L. & Zhang, X. D. (2014) Nemo-like kinase is critical for p53 stabilization and function in response to DNA damage, Cell Death Differ. 21, 1656-63.
11. Li, S. Z.*, Zhang, H. H.*, Liang, J. B., Song, Y., Jin, B. X., Xing, N. N., Fan, G. C., Du, R. L. & Zhang, X. D. (2014) Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKKbeta, Biochim Biophys Acta. 1843, 1365-72.
12. Li, S. Z.*, Song, Y.*, Zhang, H. H., Jin, B. X., Liu, Y., Liu, W. B., Zhang, X. D. & Du, R. L. (2014) UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer, Sci Rep. 4, 6910.
13. Li, S. Z.*, Zhang, H. H.*, Zhang, J. N., Zhang, Z. Y., Zhang, X. F., Zhang, X. D. & Du, R. L. (2013) ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis, Biochem Biophys Res Commun. 437, 325-30.
基金
1. 国家自然科学基金：UCHL3去泛素化稳定PPARγ在膀胱癌发生发展中的作用
机制研究（81902844），2020.01-2022.12，主持
2. 中央高校基本科研业务费医工融合项目：CLK2调节病毒诱导的炎症因子风暴研究（2021CDJYGRH-004），2021.07-2023.06，主持
3. 国家科技支撑计划（2012BAI39B03），2012.01-2014.12，参与
4. 国家重大科学研究计划（2011CB944404），2011.01-2015.12，参与
