开云全站中国有限公司党总支书记、副经理/教授，博士生导师
重庆市生物医学工程学科学术带头人（后备）
中华医学会医学科学研究管理学分会医学科技资源管理学组（筹） 副组长
中国抗癌协会肿瘤人工智能专委会 委员
中国生物医学工程康复工程专业委员会 青年委员
第一届重庆市人类遗传资源专家委员会 副主任委员
重庆市普通高校医药类专业教学指导委员会 委员
学习经历
1. 2007.05-2008.08美国密苏里大学哥伦比亚分校工程学院 中美联合培养博士
2. 2005.03-2009.12重庆老员工物工程学院生物医学工程专业 博士
3. 2002.09-2004.12重庆老员工物工程学院药物化学专业 硕士
4. 1998.09-2002.07湘潭大学化学化工学院食品科学与工程专业 学士
工作经历
1. 2023.07-至今 kaiyun开云官方网站 党总支书记、副经理、教授
2. 2018.06-2023.07 kaiyun开云官方网站 直属党支部书记、副经理、教授
3. 2017.09-2018.06 重庆老员工物工程学院 教授
4. 2016.12-2017.07 英国纽卡斯尔大学 访问学者
5. 2013.06-2014.06 kaiyun开云官方网站公司 经理助理（挂职）
6. 2012.09-2017.09 重庆老员工物工程学院副教授
7. 2009.12-2012.09 重庆老员工物工程学院讲师
研究方向、教学课程
1.新型纳/微药物递送系统；
2.生物力学（出血性脑卒中的生物力学问题）
3.生物材料的功能化改性及其在心血管领域的应用；
成果：1.文章2.专利3.项目4.获奖
近期发表的部分论文（*通讯作者#第一作者）：
1.Zhufeng Dong, Lin Tang, Yu Zhang, Xiaoyue Ma, Ying Yin, Lei Kuang, Qin Fan, Bingyi Wang, Xiaoye Hu, Tieying Yin*, Yazhou Wang*; A homing peptide modified neutrophil membrane biomimetic nanoparticles in response to ROS/inflammatory microenvironment for precise targeting treatment of ischemic stroke. Adv. Funct. Mater. 2023, 2309167
2.Luming Yang†, Zhaole Chu†, Meng Liu, Qiang Zou, Jinyang Li, Qin Liu, Yazhou Wang*, Tao Wang*, Junyu Xiang* and Bin Wang*, Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy, Journal of Hematology & Oncology, (2023) 16:59
3. Wanling Liu, Junyang Huang, Shicheng He, Ruolin Du, Shi Wen, Yang Wang, Dingyuan Du, Yan Du, Qing Liu, Yazhou Wang*, Guixue Wang*, Tieying Yin*, Senescent endothelial cells’ response to the degradation of bioresorbable scaffold induces intimal dysfunction accelerating in-stent restenosis, Acta Biomaterialia, https://doi.org/10.1016/j.actbio.2023.05.028
4.Wen Shi†, Atik Rohmana Maftuhatul Fuad†, Yanhong Li, Yang Wang, Junyang Huang, Ruolin Du, Guixue Wang, Yazhou Wang* and Tieying Yin* Biodegradable polymeric nanoparticles increase risk of cardiovascular diseases by inducing endothelium dysfunction and inflammation. J Nanobiotechnol 21, 65 (2023)
5. Xiaoyue Ma, Lei Kuang, Ying Yin, Lin Tang, Yu Zhang, Qin Fan, Bingyi Wang, Zhufeng Dong, Wei Wang, Tieying Yin*, Yazhou Wang*,Tumor–Antigen Activated Dendritic Cell Membrane-Coated Biomimetic Nanoparticles with Orchestrating Immune Responses Promote Therapeutic Efficacy against Glioma, ACS Nano, 2023, 17, 3, 2341–2355
6. Meng Yang, Bingyi Wang, Ying Yin, Xiaoyue Ma, Lin Tang, Yu Zhang, Qin Fan, Tieying Yin*, Yazhou Wang* PTN-PTPRZ1 signaling axis blocking mediates tumor microenvironment remodeling for enhanced glioblastoma treatment, Journal of Controlled Release, 353 (2023) 63–76
7. Yang Wang, Yuhua Huang, Ruolin Du, Shuang Ge, Yanhong Li, Guixue Wang, Yazhou Wang*, Tieying Yin*. The crosstalk between arterial components and the bioresorbable, 3-D printed poly-l-lactic acid scaffolds. Biomaterials Science, 2022, 10, 5121-5133 doi: 10.1039/d2bm00732k. (Front Cover)
8. Tieying Yin*, Qin Fan, Fangfang Hu, Xiaoyue Ma, Ying Yin, Bingyi Wang, Lei Kuang, Xiaoye Hu, Bo Xu, Yazhou Wang*, Engineered Macrophage-Membrane-Coated Nanoparticles with Enhanced PD-1 Expression Induce Immunomodulation for a Synergistic and Targeted Antiglioblastoma Activity, Nano Letters. 2022, 22, 16, 6606–6614
9. Ying Yin, Wei Tang*, Xiaoyue Ma, Lin Tang, Yu Zhang, Meng Yang, Fangfang Hu, Guanglin Li, Yazhou Wang*, Biomimetic neutrophil and macrophage dual membrane-coated nanoplatform with orchestrated tumor-microenvironment responsive capability promotes therapeutic efficacy against glioma, Chemical Engineering Journal, 2021, 133848. https://doi.org/10.1016/j.cej.2021.133848
10. Tieying Yin#*, Ruolin Du#, Yang Wang#, Junyang Huang, ShuangGe, Yuhua Huang, Youhua Tan, Qing Liu, Zhong Chen, Hanqing Feng,Jie Du,Yazhou Wang*, Guixue Wang*.Two-stage degradation and novel functional endothelium characteristics of a 3-D printed bioresorbable scaffold. Bioactive Materials, 2021, https://doi.org/10.1016/j.bioactmat.2021.08.0202.
11.Tieying Yin*, Yanhong Li, Yuzhen Ren, Atik Rohmana Maftuhatul Fuad, Fangfang Hu, Ruolin Du, Yang Wang, Guixue Wang and Yazhou Wang*,Phagocytosis of polymeric nanoparticles aided activation of macrophages to increase atherosclerotic plaques in ApoE−/− mice, Journal of Nanobiotechnology, 2021, 19:121
12. Jun Wang, Wei Tang*, Meng Yang, Ying Yin, Hui Li, Fangfang Hu, Lin Tang, Xiaoyue Ma, Yu Zhang, Yazhou Wang*, Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy, Biomaterials, 2021, 273: 120784
13. Ying Yin, Jun Wang, Meng Yang, Ruolin Du, Giuseppe Pontrelli, Sean McGinty, Guixue Wang, Tieying Yin, Yazhou Wang*, Penetration of the blood–brain barrier and the anti-tumour effect of a novel PLGA-lysoGM1/DOX micelle drug delivery system, Nanoscale, 2020,12, 2946-2960
14. Wei Tang; Fei Fang; Ke Liu; Zhi Huang; Hui Li; Ying Yin; Jun Wang; Guocheng Wang; Liyu Wei; Yun Ou; Yazhou Wang*, Aligned Biofunctional Electrospun PLGA-LysoGM1 Scaffold for Traumatic Brain Injury Repair, ACS Biomaterials Science & Engineering. 2020, 6, 4, 2209-2218
15. Jingjing Wang, Yuzhen Ren, Yuhua Huang, Ruolin Du, Yadong Xi, Tieying Yin*, Yazhou Wang*, Dechuan Zhang, Jinju Chen, Guixue Wang*, An asymmetrical dual coating on the stent prepared by ultrasonic atomization, J Biomed Mater Res Part B, 2019, 107(3):825-837
16. Ge, Shuang; Xi, Yadong; Du, Ruolin; Ren, Yuzhen; Xu, Zichen; Tan, Youhua; Wang, Yazhou; Yin, Tieying*; Wang, Guixue*, Inhibition of in-stent restenosis after graphene oxide double-layer drug coating with good biocompatibility, Regenerative Biomaterials, 2019, 299–309
17. Edwin J Bunggulawa; Wei Wang; Tieying Yin ; Nan Wang; Colm Durkan; Yazhou Wang*; Guixue Wang, Recent advancements in the use of exosomes as drug delivery systems, Journal of Nanobiotechnology, 2018, 16: 81-93
18. Ruolin Du# ; Yazhou Wang# ; Yuhua Huang; Yinping Zhao; Dechuan Zhang; Dingyuan Du; Yuan Zhang; Zhenggong Li; Sean McGinty; Giuseppe Pontrelli; , Tieying Yin* ; Guixue Wang*, Design and testing of hydrophobic , core/hydrophilic shell nano/micro particles for drug-eluting stent coating, NPG Asia Materials, 2018, 10:642-658 （Feature Articles）
19. Fei Fang, Dan Zou, Wei Wang, Ying yin, Tieying Yin, Shilei Hao, Bochu Wang, Guixue Wang, Yazhou Wang*. Non-invasive Approaches for Drug Delivery to the Brain Based on the Receptor Mediated Transport, Materials Science and Engineering C (2017) 76:1316-1327.
20. Dan Zou, Wei Wang, Daoxi Lei, Ying Yin, Peng Ren, Jinju Chen, Tieying Yin, Bochu Wang, Guixue Wang, Yazhou Wang*. Penetrate blood-brain barrier and enable anti-tumor and nerve repair in glioma by DOX-loaded monosialoganglioside micelles system. International Journal of Nanomedicine, 2017, 12:4879-4889
21.Sun W, Huang Y, Yin T*, Wang J, Du R, Qiu J, Zhang Y, Wang Y*, Chen J, Wang G. Effects of elemene on inhibiting proliferation of vascular smooth muscle cells and promoting reendothelialization at the stent implantation site. Biomaterials Science, 2017, 5(6), 1144-1155.
22. Yazhou Wang#, Guixue Wang*. Polymeric nanomicelles: a potential hazard for the cardiovascular system? Nanomedicine, 2017, 12(12): 1355-1358
23. Yazhou Wang*#, Wei Wang, Zong Li, Shilei Hao & Bochu Wang, A novel perspective on neuron study: damaging and promoting effects in different neurons induced by mechanical stress, Biomechanics & Modeling in Mechanobiology, 2016,15:1019–1027.
24. Yazhou Wang#*, Zong Li, Pengyu Shao, Shilei Hao, Wei Wang, Qian Yang, Bochu Wang，A novel multiple drug release system in vitro based on adjusting swelling core of emulsion electrospun nanofibers with core–sheath structure，Materials Science and Engineering C 2014; 44:109–116.
25. Hao S, Wang B, Wang Y.Porous hydrophilic core/hydrophobic shell nanoparticles for particle size and drug release control[J]. Materials Science and Engineering: C, 2015. doi:10.1016/j.msec.2014.12.029
26. Hao S, Wang B, Wang Y.Researching the dose ratio in a controlled release multiple-drug delivery system: using combination therapy with porous microparticles for the treatment of Helicobacter pylori infection[J]. Journal of Materials Chemistry B, 2015, 3(3): 417-431.
27. Hao S, Wang Y,Wang B. Sinking-Magnetic Microparticles Prepared by the Electrospray Method for Enhanced Gastric Antimicrobial Delivery[J]. Molecular pharmaceutics, 2014, 11(5): 1640-1650.
28. Hao S, Wang Y, Wang B, et al. Formulation of porous poly (lactic-co-glycolic acid) microparticles by electrospray deposition method for controlled drug release[J]. Materials Science and Engineering: C, 2014, 39: 113-119.
29. Hao S, Wang Y, Wang B, et al. A novel gastroretentive porous microparticle for anti- Helicobacter pylori therapy: Preparation,in vitro and in vivoevaluation[J]. International journal of pharmaceutics, 2014, 463(1): 10-21.
30. Yazhou Wang#, Yiqiong Zhang, Pengyu Shao, Bochu Wang, Core-shell micro/nanoparticles containing multiple drugs fabricated by emulsion electrospraying, Journal of Controlled Release 2013:172(1):e85–e86
31. Shilei Hao, Yazhou Wang, Bochu Wang, Jia Deng, Xi Liu, Junyu Liu, Rapid preparation of pH-sensitive polymeric nanoparticle with high loading capacity using electrospray for oral drug delivery, Materials Science and Engineering C, DOI:10.1016/j.msec.2013.07.009）
32. Yazhou Wang#,Guixue Wang, Liang Chen, Hao Li, Tieying Yin, Bochu Wang, James C-M Lee, Qingsong Yu. Electrospun nanofiber meshes with tailored architectures and patterns as potential tissue-engineering scaffolds, Biofabrication 2009 (1): 015001
承担和参与的科学研究项目
[1]国家自然科学基金面上项目，工程化树突状细胞膜修饰纳米粒多途径联合介导肿瘤微环境重塑增强免疫响应协同抗胶质瘤研究（32371392）；项目负责人（2024.1-2027.12）
[2]国家自然科学基金面上项目，PD-1高表达工程化双细胞膜修饰载药纳米粒响应肿瘤微环境靶向识别免疫检查点介导免疫调控协同抗胶质瘤研究（32171334）；项目负责人（2022.1-2025.12）
[3]中央高校基本科研业务费项目医工融合专项重点项目，胶质瘤靶向的透血脑屏障纳米药物递送系统的构建与评价研究（2019CDYGZD002）；项目负责人
[4]重庆市科技计划项目基础科学与前沿技术研究专项（重点项目）, 具有调控血管细胞表型的多功能药物涂层防治支架内再狭窄促进血管修复的作用及其机理研究(cstc2019jcyj-zdxmX0009)；项目负责人
[5]国家重点基础研究计划（“973”）项目：“脑出血后血肿应力对豆纹动脉神经复合体结构与功能的影响及其机制研究（2014CB541603，子课题负责人）
[6]国家自然科学基金 基于肿瘤干细胞的始动性与可塑性构建时序性联合给药微纳体系及其抗肿瘤效应的研究（31200713）；项目负责人；
[7]重庆市自然科学基金 主动靶向肿瘤干细胞（CSCs）的联合给药微纳粒构建与抗肿瘤效应研究（cstc2012jjA0549）；项目负责人；
[8]教育部高等学校博士学科点科研基金(20120191120058)；项目负责人
[9]中央高校基本科研业务费重点项目基于脑重大疾病异常微环境下神经组织损伤机制与修复研究(2015CDJZR)；项目负责人；
[10]国家科技支撑计划 新型药物缓释冠脉支架（2012BAI18B02）；项目研究骨干（排名第三）
相关奖励与荣誉
[1] 2010年度kaiyun开云官方网站优秀博士论文
[2] 2011年度重庆市优秀博士论文
[3] 2011年度kaiyun开云官方网站黄尚廉员工创新奖
[4]2014年度kaiyun开云官方网站先进工作者
